TR Pro+ - Tissue Repair

Tissue Repair Pro is a hydrogel that helps damaged skin by creating an environment that supports the healing process. TR Pro+® hydrates skin internally whilst providing a barrier to reduce transepidermal water loss, is able to cool and soothe skin and is effective in reducing the irritation and redness that often follows aesthetic and other minor surgical procedures.

Key Ingredients:

- Beta-glucan (Glucoprime®) – a naturally derived sugar that is purified from the cell wall of baker’s yeast which has immunomodulatory properties that support skin regeneration

- Triethanolamine – balances the pH of the gel to avoid irritation to your skin

- Carbomer – allows the gel to retain water to provide you with a soothing texture and leave your skin looking bright

When TR Pro+® is applied topically, the Glucoprime® moves between the cells of the epidermis to the dermis where it comes into contact with macrophages. These macrophages are the ‘guard cells’ and are on alert for foreign pathogens like bacteria and yeast.

TR Pro+® stimulates macrophages to manage the healing process

Healing is a complex process that involves many different cellular components being switched on and off at the appropriate time and in the correct concentrations. Macrophages are the cells that coordinate the healing process which occurs in four phases – haemostasis, inflammation, proliferation and remodelling.

As the healing process moves from inflammation to proliferation, the macrophages transition from the M1 to the M2 type and adjust the environment to one which supports skin regeneration. M2 macrophages produce a different array of cytokines and growth factors which enables the production of collagen, the restoration of the barrier function and the generation of new capilliaries. This proliferative phase may last for 4-24 days.

M2 macrophages are essential to build new tissue through the generation of types I and III collagen. The tissue regeneration bought about by TR Pro+® is effective for medical procedures (eg: excision, biopsy, skin cancer removal) as well as aesthetic procedures (eg: laser, all types of skin needling and chemical peels).

TR Pro+® has been shown in laboratory studies to increase the number of M2 macrophages and in this way accelerate healing and improve skin quality (Mills et al. 2024).

Hydrogels are the wound dressing of choice and can benefit all stages of healing:

Can be used for different types of wounds (closed, open, weeping or dry)

Cleansing phase: supports the removal of exudate, cell debris, foreign bodies and germs (autolytic debridement)

Granulation phase: optimally moisturise and provide a hydrated matrix which promotes cell migration into the wound, and supports collagen synthesis and cross-linking

Reparative phase: re-epithelialisation is promoted by division of keratinocytes, optimally supplied with oxygen.

TR Pro+® supports skin regeneration in many ways:

- Film-forming, Flexible, Full Contact

TR Pro+® dries to form a thin, transparent and durable protective film that stays in constant contact with the skin.

- Wound Healing and Scar Formation

TR Pro+® absorbs exudate leading to improved wound healing5. Increased hydration provides an environment favourable to normal scar formation (Muthuramalinga et al. 2019).

- Protection

TR Pro+® provides a barrier that protects against microbial infection while at the same time allowing the skin to breathe (Pillai et al. 2005).

- Cooling Effect

TR Pro+® provides a cooling effect to soothe damaged skin and helps relieve pain and itching. Heat generated from cosmetic procedures is able to dissipate freely (Pillai et al. 2005).

- Stops Bleeding

TR Pro+® acts as a haemostatic agent to stem bleeding and manage exudate (Madaghiele et al. 2014).

- Easy to Use and Non-reactive 

TR Pro+® can be applied once daily, is non-greasy, and can easily be removed from clothes. TR Pro+® is neutral pH, and does not contain any preservatives, fragrances, or parabens making it suitable for people with sensitive skin.